TY - JOUR T1 - Protein sorting at the trans-Golgi network. JF - Annu Rev Cell Dev Biol Y1 - 2014 A1 - Yusong Guo A1 - Sirkis, Daniel W A1 - Schekman, Randy KW - Adaptor Proteins, Vesicular Transport KW - ADP-Ribosylation Factor 1 KW - Amino Acid Motifs KW - Animals KW - Carrier Proteins KW - Cell Polarity KW - Cytosol KW - Humans KW - Membrane Lipids KW - Membrane Transport Proteins KW - Models, Biological KW - Models, Molecular KW - Phospholipids KW - Protein Conformation KW - Protein Sorting Signals KW - Protein Transport KW - Structure-Activity Relationship KW - trans-Golgi Network KW - Transport Vesicles KW - Vesicular Transport Proteins AB -

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where newly synthesized proteins are packaged into distinct transport carriers that are targeted to various destinations. To maintain the fidelity of protein transport, elaborate protein sorting machinery is employed to mediate sorting of specific cargo proteins into distinct transport carriers. Protein sorting requires assembly of the cytosolic sorting machinery onto the TGN membrane and capture of cargo proteins. We review the cytosolic and transmembrane sorting machinery that function at the TGN and describe molecular interactions and regulatory mechanisms that enable accurate protein sorting. In addition, we highlight the importance of TGN sorting in physiology and disease.

VL - 30 ER -