TY - JOUR T1 - Characterization of breast cancer by array comparative genomic hybridization. JF - Biochem Cell Biol Y1 - 2007 A1 - Climent, J A1 - Garcia, J L A1 - Jiang-Hua Mao A1 - Arsuaga, J A1 - Perez-Losada, J KW - Breast Neoplasms KW - Computational Biology KW - Cytogenetic Analysis KW - Female KW - Gene Expression Profiling KW - Genetic Predisposition to Disease KW - Humans KW - Oligonucleotide Array Sequence Analysis KW - Prognosis AB -

Cancer progression is due to the accumulation of recurrent genomic alterations that induce growth advantage and clonal expansion. Most of these genomic changes can be detected using the array comparative genomic hybridization (CGH) technique. The accurate classification of these genomic alterations is expected to have an important impact on translational and basic research. Here we review recent advances in CGH technology used in the characterization of different features of breast cancer. First, we present bioinformatics methods that have been developed for the analysis of CGH arrays; next, we discuss the use of array CGH technology to classify tumor stages and to identify and stratify subgroups of patients with different prognoses and clinical behaviors. We finish our review with a discussion of how CGH arrays are being used to identify oncogenes, tumor suppressor genes, and breast cancer susceptibility genes.

VL - 85 IS - 4 U1 - http://www.ncbi.nlm.nih.gov/pubmed/17713584?dopt=Abstract ER -