@article {281,
	title = {Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation.},
	journal = {Sci Rep},
	volume = {3},
	year = {2013},
	month = {2013},
	pages = {2234},
	abstract = {<p>Giant magnetoresistive (GMR) nanosensors provide a novel approach for measuring protein concentrations in blood for medical diagnosis. Using an in vivo mouse radiation model, we developed protocols for measuring Flt3 ligand (Flt3lg) and serum amyloid A1 (Saa1) in small amounts of blood collected during the first week after X-ray exposures of sham, 0.1, 1, 2, 3, or 6 Gy. Flt3lg concentrations showed excellent dose discrimination at >= 1 Gy in the time window of 1 to 7 days after exposure except 1 Gy at day 7. Saa1 dose response was limited to the first two days after exposure. A multiplex assay with both proteins showed improved dose classification accuracy. Our magneto-nanosensor assay demonstrates the dose and time responses, low-dose sensitivity, small volume requirements, and rapid speed that have important advantages in radiation triage biodosimetry.</p>
},
	keywords = {Animals, Biomarkers, Biosensing Techniques, Blood Proteins, Dose-Response Relationship, Radiation, Female, Male, Membrane Proteins, Mice, Nanotechnology, Radiation, Ionizing, Radiometry, Reproducibility of Results, Serum Amyloid A Protein, Time Factors},
	issn = {2045-2322},
	doi = {10.1038/srep02234},
	author = {Kim, Dokyoon and Marchetti, Francesco and Chen, Zuxiong and Zaric, Sasa and Wilson, Robert J and Hall, Drew A and Gaster, Richard S and Lee, Jung-Rok and Wang, Junyi and Osterfeld, Sebastian J and Yu, Heng and White, Robert M and Blakely, William F and Peterson, Leif E and Bhatnagar, Sandhya and Mannion, Brandon and Tseng, Serena and Roth, Kristen and Coleman, Matthew and A Snijders and Wyrobek, Andrew J and Wang, Shan X}
}
