@article {280,
	title = {DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood.},
	journal = {PLoS One},
	volume = {7},
	year = {2012},
	month = {2012},
	pages = {e48619},
	abstract = {<p>DNA damage and repair are hallmarks of cellular responses to ionizing radiation. We hypothesized that monitoring the expression of DNA repair-associated genes would enhance the detection of individuals exposed to radiation versus other forms of physiological stress. We employed the human blood ex vivo radiation model to investigate the expression responses of DNA repair genes in repeated blood samples from healthy, non-smoking men and women exposed to 2 Gy of X-rays in the context of inflammation stress mimicked by the bacterial endotoxin lipopolysaccharide (LPS). Radiation exposure significantly modulated the transcript expression of 12 genes of 40 tested (2.2E-06</p>

<p>\&nbsp;</p>
},
	keywords = {Adult, Biomarkers, Cell Cycle, DNA Repair, Dose-Response Relationship, Radiation, Female, Gene Expression Regulation, Humans, Inflammation, Lipopolysaccharides, Male, Middle Aged, Phosphorylation, Predictive Value of Tests, Reproducibility of Results, RNA, Messenger, Stress, Physiological, Time Factors, Transcription, Genetic, X-Rays, Young Adult},
	issn = {1932-6203},
	doi = {10.1371/journal.pone.0048619},
	author = {Budworth, Helen and A Snijders and Marchetti, Francesco and Mannion, Brandon and Bhatnagar, Sandhya and Kwoh, Ely and Tan, Yuande and Wang, Shan X and Blakely, William F and Coleman, Matthew and Peterson, Leif and Wyrobek, Andrew J}
}
